This grant (R01HL158577; PI: Schreier) takes advantage of a large, well-characterized, prospective cohort of youth who were recently investigated for child maltreatment and comparison youth without a maltreatment history to better understand the physiological mechanisms between early adversity and cardiovascular diseases risk. By taking advantage of detailed assessments of immune function coupled with administrative health care records and thorough behavioral and psychosocial assessments, we will prospectively examine links between child maltreatment and cardiovascular disease risk, with the hopes of informing future prevention and intervention efforts.